All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit the MDS Alliance

The MDS Hub uses cookies on this website. They help us give you the best online experience. By continuing to use our website without changing your cookie settings, you agree to our use of cookies in accordance with our updated Cookie Policy

MDS-related mutations

MDS-related mutations

The accumulation of mutations drives disease evolution from asymptomatic clonal hematopoiesis to MDS. The study and identification of MDS-related mutations can be crucial for diagnosis, risk stratification, and, ultimately, therapy decision. Most MDS cases are caused by somatic mutations in DNMT3A, TET2, SF3B1, and TP53, but they can also be caused by inherited mutations in genes like DKC1, TERC, RUNX1, ETV6, GATA2, or SBDS.

|||