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Prolyl hydroxylase inhibitors

Prolyl hydroxylase inhibitors

Inhibitors of the prolyl hydroxylase (PH) domain enzyme can stabilize the hypoxia-inducible factor, which stimulates erythropoietin synthesis. Therefore, these promising novel agents are developed to treat different types of anemia associated with chronic diseases. Some orally active PH inhibitors, like roxadustat, are in advanced clinical trials.

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