How should we manage HMA failure?

During the 7th European School of Haematology (ESH) Translational Research Conference on Myelodysplastic Syndromes, the MDS Hub spoke to Valeria Santini, University of Florence, Florence, IT. We asked, How should we manage hypomethylating agent (HMA) failure?

Santini firstly discusses when to assess HMA failure in patients with MDS. She then provides an overview of new agents for de novo, high-risk MDS. This includes a new HMA (guadecitabine), a BCL2 inhibitor (venetoclax), and immunotherapy (magrolimab and sabatolimab). She also evaluates targeting agents (ivosidenib and enasidenib) for relapsed/refractory MDS. Santini finishes by discussing APR-246, a new agent for patients with TP53 mutations, who have the worst prognosis.