How does COVID-19 infection affect hematopoiesis in MDS?

During the ESH 2nd Translational Research Conference: Erythropoiesis Control and Ineffective Erythropoiesis - From Bench to Bedside, the MDS Hub spoke to Eric Solary, Gustave Roussy, Paris, FR. We asked, How does COVID-19 infection affect hematopoiesis in MDS?

In the majority of COVID-19 infections, the virus induces an effective antiviral, interferon response. However, for a minority with severe disease, a stress hematopoiesis response is detected, preventing patients from building an appropriate immune response. Patients with MDS could be predisposed to the virus since the hematopoietic response in the severe form of COVID-19 resembles that of acute MDS. For that reason, Solary urges patients to remain cautious and get immunized.