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As of January 1st, 2024, the MDS Hub will no longer be updated. Please continue to browse our archive for valuable content. For the latest updates in MDS, visit our sister site aml-hub.com.
2020-06-30T14:05:38.000Z

Is azacitidine + APR-246 safe and effective in TP53 mutated MDS and AML?

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During the 25th Congress of the European Hematology Association (EHA), the MDS Hub spoke to Thomas Cluzeau, Centre Hospitalier Universitaire de Nice, Nice, FR. We asked: Is azacitidine + APR-246 safe and effective in patients with TP53 mutated MDS and acute myeloid leukemia?

Is azacitidine + APR-246 safe and effective in TP53 mutated MDS and AML?

Results from the phase II study, evaluating the novel p53-activating drug, APR-246, + azacitidine for the treatment of patients with TP53 mutated MDS and acute myeloid leukemia, were presented at this year's EHA meeting. The combination has demonstrated a manageable toxicity profile and promising clinical efficacy in this setting.

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