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Can changes in DNA methylation pattern predict the response to HMA in MDS?

During the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, the MDS Hub spoke to Rafael Bejar, University of California San Diego, San Diego, US. We asked, Can changes in DNA methylation pattern predict the response to hypomethylating agents (HMA) in MDS.

Can changes in DNA methylation pattern predict the response to HMA in MDS?

Bejar discusses a study from ASH 2020, examining whether DNA methylation status before and during therapy could predict eventual response in patients treated with azacitidine plus the novel agent pevonedistat.

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