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The MDS Hub Steering Commitee met on May 5, 2022. The recorded discussion was chaired by Rena Buckstein, and featured Theo de Witte, Silvia Magalhães, and Yasushi Miyazaki. The topic of this discussion, “What patient factors should we consider for intermediate- and high-risk patients beyond the IPSS-R score?”, was identified as an unmet educational need within MDS treatment.
What patient factors should we consider for intermediate- and high-risk patients beyond the IPSS-R score?
Buckstein begins by discussing two case studies, and the use of IPSS-R to define risk. De Witte talks about the effect that comorbidities can have on patient outcomes, and the committee discusses the treatment options and possible outcomes of the case study patients. Buckstein presents information on prognostic factors and the significance of mutations in prognosis. The committee also discusses how to calculate prognostic factors to decide treatment strategies, determine survival, and counsel patients. Buckstein then explains which genes are included in the IPSS-Molecular (IPSS-M) calculations. Finally, the committee discusses how the IPSS-M could be implemented in clinical settings, including potential problems.
Real-world validation of the IPSS-M risk stratification model for MDS and comparison to IPSS-R
The MDS Hub summarizes several presentations from ASH 2022 discussing the implementation of IPSS-M and comparing the prognostic ability of this model with...
Challenges of measuring overall survival in elderly patients with MDS
During the MDS Hub Steering Committee meeting held on November 14, 2022, Theo de Witte chaired a discussion on the challenges of measuring overall survival in elderly patients with...
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