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How do we treat high-risk patients outside of a clinical trial?

The MDS Hub Steering Commitee met on May 5, 2022. The recorded discussion was chaired by Theo de Witte, and featured Rena Buckstein, and Yasushi Miyazaki. The topic of this discussion, “How do we treat high-risk patients outside of a clinical trial?”, was identified as an unmet educational need within MDS treatment.


How do we treat high-risk patients outside of a clinical trial?

De Witte discusses approaches to treat high-risk patients, including following the current guidelines in MDS treatment, and potential new drugs that may become approved by the U.S. Food and Drug Administration (FDA). Buckstein discusses the use of hypomethylating agents, and what factors she considers when treating patients with these drugs, such as cytotoxicity. Miyazaki talks about using azacitadine in high-risk patients, following the Japanese guidelines.