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The MDS Hub was pleased to speak to Theo de Witte, Radboudumc, Nijmegen, NL. We asked, What are the highlights of the ESH 8th Translational Research Conference: Myelodysplastic Syndromes?
Highlights of the 8th Translational Research Conference: Myelodysplastic Syndromes
De Witte begins by discussing new molecular MDS-specific mutations and how they can impact diagnosis and prognosis. De Witte goes on to define the pre-stages of MDS and myeloproliferative neoplasms (MPN), in particular clonal hematopoiesis of indeterminate potential (CHIP), and clonal cytopenia of undetermined significance (CCUS).
CCUS with dysplasia: A clinically relevant precursor to MDS
Clonal hematopoiesis of indeterminate potential (CHIP) evolves into hematologic cancers at a much slower rate compared to clonal cytopenia of undetermined significance (CCUS). CCUS therefore...
Editorial theme | Immune dysregulation and genetic mutations associated with MDS pathogenesis
The pathogenesis of myelodysplastic syndromes (MDS) is heterogeneous, involving inflammation, cytokines, growth factors, the accumulation of genetic damage,...
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