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ASH 2022

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Dec 10, 2022


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27 May 2023

Weekend catch up:
Promising outcomes of novel treatments (sabatolimab, imetelstat, and canakinumab) in patients with MDS were presented at the oral abstract session of #ASH22. Check out our summary here 👉 https://t.co/UXYfqS0wWb.

#mdssm
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3 Mar 2023

Promising outcomes of novel treatments (sabatolimab, imetelstat, and canakinumab) in patients with MDS were presented at the oral abstract session of #ASH22.
Check out our summary here 👉 https://t.co/UXYfqS0wWb. #mdssm
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6 Feb 2023

🎥 #ASH22 | The MDS Hub was pleased to speak to Theo de Witte, Radboud University Medical Center, Nijmegen, NL. We asked, Is there confusion between WHO and IPSS-M classifications of MDS?
👉 https://t.co/jkVX37wn7V. #Lymsm
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14 Dec 2022

We hope you enjoyed following our live updates and congress coverage from #ASH22!

Keep an eye on our socials for post-congress key points and insights!

#hematology #medicalcongress #cancerresearch #cancerawareness #medicaleducation #mdssm
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13 Dec 2022

RT @MPN_Hub: CONGRESS | #ASH22
Drew Weissman, @WeissmanLab outlines the history of mRNA concluding with the development of the COVID-19 mRN…
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13 Dec 2022

RT @lymphomahub: CONGRESS |#ASH22
@bhwords of @GSTTnhs discusses the how COVID-19 has brought unforeseen challenges to the thrombosis comm…
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13 Dec 2022

RT @AML_Hub: CONGRESS | #ASH22
@profshanecrotty from @ljiresearch discusses SARS-CoV-2 and data gathered to access immunological memory pos…
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13 Dec 2022

CONGRESS | #ASH22
Saverio D’Amico, @HumanitasMilano, explained that development of a federated learning algorithm allows for clinical implementation.
#mdssm #medicalcongress
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13 Dec 2022

CONGRESS | #ASH22
Saverio D’Amico, of @HumanitasMilano, presented a machine/deep learning learning approach for prognostic assessment and classification in MN. Survival prediction models were compared across 2043 patients with MDS.
#mdssm #medicalcongress
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12 Dec 2022

RT @AML_Hub: Congress | #ASH22 Daniel Weisdor, @UMNHOT provides an insightful overview of transplant in patients with R/R AML and high-risk…
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12 Dec 2022

RT @AML_Hub: Congress | #ASH22 @ColemanLindsley @DanaFarber gives a thought-provoking presentation on transplantation in pts with TP53-muta…
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12 Dec 2022

CONGRESS | #ASH22
Guillermo Garcia-Manero discussed a phase II trial of canakinumab in pts with lower-risk #MDS. Canakinumab was found to decrease the frequencies of HSCs and MPPs. Canakinumab was safe and there were no severe AEs.
#MDSsm #medicalcongress
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12 Dec 2022

CONGRESS | #ASH22
Inga Mandac Smoljanovic continues by reporting duration of response to lenalidomide = 88% vs 60% in patients without del(5q). Lenalidomide did not impact OS or progression.
#mdssm
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12 Dec 2022

CONGRESS | #ASH22
Inga Mandac Smoljanovic, Clinical Hospital Merkur, describes an analysis of patients with MDS isolated del(5q) in the EUMDS registry. Response to lenalidomide was highest in MDS dl(5q) with low transfusion burden.
#mdssm
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12 Dec 2022

Keep an eye on our Twitter page!

The @MDS_Hub will be bringing you comprehensive updates as we continue our live coverage of #ASH22.

Sessions covered today:

637 and poster sessions

#hematology #medicalcongress #cancerresearch #mdssm
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12 Dec 2022

CONGRESS | #ASH22
Amer Zeidan @Dr_AmerZeidan reports severe neutropenia/agranulocytosis = 3.5% in the registry, and 13.3% in the CPU, but highlights limitations of non-randomized, uncontrolled real-world studies. #mmsm
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12 Dec 2022

CONGRESS | #ASH22
Amer Zeidan @Dr_AmerZeidan of @Yale explains that no new or unexpected AEs were seen in patients with MDS treated with the oral iron chelator deferiprone in a US safety registry (n = 115) and compassionate use program (CPU) (n = 15).
#mdssm
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11 Dec 2022

CONGRESS | #ASH22
Naval Daver @Daver_Leukemia, @MDAndersonNews presented phase Ib/II trial of pivekimab sunirine (PVEK)+Aza+Ven triplet in R/R AML. In 91 patients, ORR = 45% and composite CR = 25% (duration 7.7 months), with a manageable safety profile. #leusm
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11 Dec 2022

CONGRESS | #ASH22
Maria Diez-Campelo @madicamp reports improvements of 77.8% and 94.1% in erythroid and cytogenetic response, respectively, with lenalidomide vs placebo, and no increase in AML progression.
#mdssm
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11 Dec 2022

CONGRESS | #ASH22
Maria Diez-Campelo @madicamp @IBSAL_IIS describes low dose lenalidomide in anemic non-transfusion-dependent low risk MDS del(5q) (n = 61) delayed and decreased transfusion dependency (25%) vs placebo (65%) in the phase III Sintra-REV trial.
#mdssm
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11 Dec 2022

CONGRESS | #ASH22
Uwe Platzbecker @UwePlatzbecker reports that of 38 patients with non-del(5q) and no prior lenalidomide/HMA treatment, 11 (29%) achieved TI ≥1 year. Median TI duration = 92.4 weeks, PFS = 34.2 & OS = 56.1 months.
#mdssm
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11 Dec 2022

CONGRESS | #ASH22
Uwe Platzbecker @UwePlatzbecker, @UniLeipzig, presents phase II data from IMerge trial of the first-in-class telomerase inhibitor imetelstat in RBC transfusion-dependent and erythropoiesis stimulating agent R/R lower-risk MDS.
#mdssm
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11 Dec 2022

CONGRESS | #ASH22 Valeria Santini, @UNI_FIRENZE compares IPSS, IPSS-R, and IPSS-M scoring systems in the phase II STIMULUS-MDS1 and phase III STIMULUS-MDS2 patient populations. Results indicate that molecular and cytogenetic assessment will improve evaluation in clinical trials.
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11 Dec 2022

CONGRESS | #ASH22 @jadothm @kingsmedicine @KingsCollegeLon present results from the UK NCRI AML 19 trial where CPX-351 had a significant survival benefit over FLAG-Ida in young high-risk pts with mutationally defined secondary AML/MDS. #MDSsm #leusm
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11 Dec 2022

CONGRESS | #ASH22 @drsomedeb @MoffittNews shares insight into a retrospective analysis validating the genetic and morphologic WHO and ICC subtypes of #MDS. A blast cut-off of 5% correlated with outcomes better than 10%, and mTP53 predicted the lowest OS in both systems. #leusm
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11 Dec 2022

CONGRESS | #ASH22 Constance Baer, @leukaemielabor discusses a validation of IPSS-M and comparison to Nazha et al. and Bersanelli et al. models. The increased predictive power of IPSS-M over IPSS-R was confirmed. The new scoring systems had varying abilities to predict outcomes.
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11 Dec 2022

CONGRESS | #ASH22 @LeafOnc @MoffittNews gives an exciting overview of the validation of the IPSS-M scoring system at Moffitt Cancer Center. IPSS-M improved the discrimination of LFS, OS, and risk of leukemic transformation over IPSS-R in pts with #MDS. #MDSsm #leusm
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11 Dec 2022

CONGRESS | #ASH22 Elisabetta Sauta, AI Center, Humanitas Research Hospital, Milan, presents an independent validation of the IPSS-M scoring system in a real-world population. IPSS-M was found to improve #MDS prognostication and may lead to better selection of pts for HSCT. #leusm
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11 Dec 2022

Keep an eye on our Twitter page!

The @MDS_Hub will be covering the following session(s) today:
617 and 637

Stay tuned for live updates, key insights, and interview coverage!
#ASH22 #hematology #medicalcongress #cancerresearch #mdssm
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11 Dec 2022

CONGRESS | #ASH22 @MukherzSudipto @ClevelandClinic presents results from a retrospective analysis where >90% of patients with LR-MDS and low transfusion at baseline burden achieved transfusion independence within the first 24 weeks of luspatercept treatment. #MDS #leusm
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10 Dec 2022

Congress | #ASH22 @RohitBanwar @UVMcancercenter presents data from an analysis of the impact of concomitant autoimmune disease on pts with non-high-risk #MDS. Autoimmune disease was associated with an increased risk of AML transformation but a decreased risk of mortality. #MDSsm
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10 Dec 2022

Congress | #ASH22 Dr. Gregor Hoermann, @leukaemielabor presents a comparative analysis of the 2022 WHO and ICC guidelines. While the basic concepts of classification were similar, there were non-comparable diagnoses in a subset of patients. #MDSsm #leusm
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10 Dec 2022

Congress | #ASH22 Dr. Sylvie Freeman, @ImmunologyUoB presents results from the NCRI AML18 trial. Fractionated schedule of gemtuzumab ozogamicin was associated with a greater reduction of MRD and improved overall survival compared to single-dose gemtuzumab ozogamicin. #leusm
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9 Dec 2022

The @MDS_Hub will be covering the 64th ASH Annual Meeting & Exposition!

🗓 Date: Dec 10–13
📍 Location: New Orleans and online

Keep an eye on our socials for live coverage throughout the day from our virtual and in-person attendance!

#ASH22 #mdssm
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6 Dec 2022

Get ready for #ASH22 with us! 
The list of top abstracts selected by our steering committee for the 64th @ASH_hematology Annual Meeting and Exposition is now available on the @MDS_hub!
📌Find out more: https://t.co/9EsQhePRL6
#ASH2022 #mdssm #medicalabstracts #cancer
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30 Nov 2022

#ASH22 is almost upon us!
To help navigate the exciting sessions, check out our top abstract list to see what’s hot in #MDS 👉 https://t.co/9EsQhePRL6. #MDSsm #leusm #medicalcongress

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